Classic coagulation laboratory tests, such as activated partial thromboplastin time (APTT), prothrombin time (PT), and platelet count, mainly indicate signs of consumption and impaired synthesis instead of ongoing coagulopathy, and change slowly in the disease course (9, 10), and as a result, they might not be particularly available for identifying coagulopathy in the early stages of a patient's illness, which makes therapy monitoring difficult among sepsis patients. Here, F2 is linked to blood coagulation disease.