Mei et al. (10) conducted a multi-center, prospective and observational study, and demonstrated that TAT, t-PAIC, and soluble thrombomodulin (TM) increased in patients with DIC in adult sepsis, but not PIC, demonstrating sepsis patients' coagulation activation, and fibrinolytic inhibition and endothelial injury. This evidence concerns the gene THBD and Sepsis.