In a 6-month randomized crossover study by Winer et al in 8 adult patients with postsurgical hypoparathyroidism, pump delivery of synthetic hPTH(1-34), compared with twice-daily injections, resulted in less fluctuation in serum calcium concentrations, over 50% reduction in urinary calcium, 65% reduction in the PTH dose to maintain normal calcium concentration, and higher serum magnesium concentrations [22]. This evidence concerns the gene PTH and hypoparathyroidism.