Gefitinib‐resistant (GR) NSCLC cells have also been shown to exhibit Cx26 upregulation, and knocking down this connexin reverses GR and EMT progression in both HCC827‐GR and PC9‐GR cells through a mechanism dependent upon PI3K/Akt signaling.35 Here, AKT1 is linked to non-small cell lung carcinoma.