IDH1 and central nervous system cancer: Analysis of the TCGA cohort revealed that low expression of CSMD1 in glioma is linked to a decline in both overall survival (OS) time (Fig. 1A) disease-free survival (DFS) time (Fig. 1B), non-co-deleted 1p/19q genotype (Fig. 1C) and wt-IDH phenotype (Fig. 1D).