LPL and hypertriglyceridemia: LPL stands out as one of the most extensively studied human disease genes, with investigations spanning from a Mendelian disorder recognized as autosomal recessive familial chylomicronemia syndrome (FCS), also known as type I hyperlipoproteinemia or LPL deficiency [3], to a complex trait, hypertriglyceridemia (HTG) [4, 5], and its associated conditions, including HTG-induced acute pancreatitis (HTG-AP) [6].