In obesity-related liver carcinoma, a different model of SASP-mediated immunosuppression, it was demonstrated that the cooperation between the hepatic translocation of the obesity-induced gut microbial component lipoteichoic acid (LTA), and the production of the obesity-induced gut microbial metabolite, deoxycholic acid, enhanced induction of SASP and the activity of COX2 in hepatic stellate cells (HSCs), by a Toll-like receptor 2 mechanism. The gene discussed is TLR2; the disease is obesity due to melanocortin 4 receptor deficiency.