The authors found a stark switch from an immunosuppressive tumor environment characterized by exhausted T lymphocytes to an immunocompetent setting with functional CD8+ T lymphocytes and active macrophages following senescence induction attributing these changes to a cell-surface proteome remodeling of SnCs, which includes the increase of antigen-presenting machinery and heightened responsiveness to IFN-γ [54]. This evidence concerns the gene IFNG and neoplasm.