Mutations in FGFR2 have been linked to numerous medical syndromes, such as Apert syndrome (OMIM 101200) [28], Beare-Stevenson cutis gyrata syndrome (OMIM 123790) [29], Crouzon syndrome (OMIM 123500) [28], Jackson-Weiss syndrome (OMIM 123150) [29], Lacrimo-Auriculo-Dento-Digital (LADD) syndrome (OMIM 149730) [30], and Pfeiffer syndrome (OMIM 101600) [29]. Here, FGFR2 is linked to Cutis gyrata - acanthosis nigricans - craniosynostosis.