APP and amyloidosis: Transgenic mice with amyloid pathology (due to expression of mutant human amyloid precursor protein, APP) had increased proinflammatory cytokine expression in the brain when injected intraperitoneally with LPS (0.3 mg/kg), relative to wild-type mice, indicating a synergy between amyloid and LPS in inducing neuroinflammation (Knopp et al. 2022).