Mutations of MAPT, the gene encoding TAU, cause primary tauopathies such as progressive supranuclear palsy (PSP), but are not associated with secondary tauopathies such as AD, i.e. AD patients do develop tauopathy, but without obligatory MAPT mutations (Bellenguez et al. 2022). This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.