Our study has revealed systematic nucleosome changes in tumour cells that occur at two levels: (i) Small-scale changes at the level of individual nucleosomes corresponding to differential gene expression and TF binding (Figs. 1 and 2); (ii) A genome-wide decrease in the NRL in tumour tissue (which holds true in all types of genomic regions that we analysed), as summarised in Fig. 5F. The gene discussed is TF; the disease is neoplasm.