The increased expression of HIF-1 dependent S100A10 can form complexes and interact with histone demethylase KDM6A, ultimately being recruited to the OCT4 binding site to erase H3K27 trimethylation chromatin markers and promote transcription of NANOG, SOX2 and KLF4 in breast cancer [209]. The gene discussed is SOX2; the disease is breast carcinoma.