Furthermore, in contrast to traditional diagnostic marker carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9), serum Cyr61 exhibit superior diagnostic and prognostic efficacy for CRC according to multivariate logistic regression analysis and receiver operating characteristic (ROC) area under the ROC curve (AUC) of 0.933 [83]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.