Besides, exosomal circ-0072088 can sponge with miR-375 and upregulate MMP-16 to suppress HCC metastasis, and exosomal hsa_circ_0051443 can bound to miR-331-3p to upregulate BAK1 which in turn suppresses HCC progression [161, 162]. The gene discussed is MMP16; the disease is hepatocellular carcinoma.