CXCL12 and colorectal carcinoma: Wang et al. found that CAFs tend to uptake miR-146a-5p and miR-155-5p via exosomes to promote CRC metastasis via activating NF-κB/JAK2–STAT3 signaling to upregulate the expression of inflammatory cytokines including tumor necrosis factor-α, interleukin-6, CXCL12, and TFG-β which trigger EMT and facilitate CRC distant metastasis [43].