within the cohort comprising of 89 HCC patients and 60 normal controls, plasmatic exosomal LncRNA THEMIS2-211 is upregulate in HCC patients (p < 0.001), and the diagnostic efficiency of exosomal THEMIS2-211 experiences a notable improvement when combinate with AFP in diagnosing stage I HCC patients [121]. This evidence concerns the gene THEMIS2 and hepatocellular carcinoma.