Li and jiang et al. discerned that the expression of exosomal LOXL4, and ENO1 is also been identified to be overexpressed in HCC patients and intimately associated with the tumor-node-metastasis (TNM) stage, and the protein within serum-derived exosomes is intricately linked to an unfavorable prognosis in HCC patients [81, 82]. This evidence concerns the gene LOXL4 and hepatocellular carcinoma.