KRAS and colorectal carcinoma: Babak et al. found that exosomal miR-143 and miR-100 effectively downregulate mTOR, K-RAS, HK2, and Cyclin D1 while significantly suppressing the expression of MMP9, MMP2, TWIST, and SNAIL; and upregulating p-27 expression, thus hampering CRC proliferation, migration, invasion, and metastasis [156].