Aligning with this change, sialylated SERPINA1 were up-regulated in early-stage oropharyngeal squamous cell carcinoma [53] and in metastatic HCC compared to non-metastatic HCC group [54], suggesting that sialylated SERPINA1 was closely associated with HCC. This evidence concerns the gene SERPINA1 and oropharynx squamous cell carcinoma.