CDKN2C and Familial prostate cancer: For example co-deletion of p18INK4c and p53 lead to development of medulloblastomas, hemangiosarcomas, and other tumors not present in either of the parental strains or deletion of p18INK4c in PTEN−/− background resulted in emergence of various tumors such as pituitary or prostate cancers [272, 273].