On the other hand, several reports show that relocation of p27KIP1 into the cytoplasm leads not just to disinhibition of nuclear CDKs, but also has pro-tumorigenic role and cytoplasmic localization of p27KIP1 is associated with poor prognosis and patient survival with osteosarcoma [122], lung carcinoma [123], hepatocellular carcinoma [124], urothelial carcinoma [86], renal carcinoma [125] and melanoma [126]. Here, CDKN1B is linked to osteosarcoma.