CASP3 and non-small cell lung carcinoma: To study the impact of varying nanodrugs on the expression of Bax and Caspase-3 proteins in DDP-resistant cells, it was found that the Bax and Caspase-3 protein bands in Lipo@DDP@miR-219a-5p@FA group were significantly increased, mainly due to reversal effect of miR-219a-5p on DDP-resistant cells, which had a significant inhibitory effect on the growth of DDP-resistant NSCLC cells in combination with DDP.