PDPN and neoplasm: C-type lectin-like receptor 2 (CLEC-2) is a receptor for podoplanin that is expressed on the surface of platelets and facilitates tumour cell metastasis by inducing platelet activation, aggregation and the secretion of bioactive molecules, ultimately facilitating tumour cell survival, adhesion to the vessel wall, extravasation to new metastatic sites and growth [5, 12–18].