Additionally, Pten was discovered in 1997 independently by three laboratories as a tumor suppressor of which the expression is often lost in tumors [51–53], and several miRNAs (including miR-205, miR-122, miR-21, etc.)have been identified as binding to the 3' untranslated region of Pten mRNA [54–56]. The gene discussed is PTEN; the disease is neoplasm.