On the other hand, many reports suggest that cardiac glycosides may be potential chemicals for cancer, because they inhibit cell proliferation through multiple pathways, including activation of Src/MAPK signaling, induction of intracellular Ca2+ signaling, and inhibition of PI3K/AKT/mTOR, HIF-1, and Wnt/β-catenin signaling [19–21]. The gene discussed is AKT1; the disease is cancer.