HAVCR2 and cancer: Therefore, we next evaluated the other hallmarks of cancer T cell exhaustion that may be exhibited by the TILs subset, namely the coexpression of multiple inhibitory receptors such as Tim-3, PD-1 and TIGIT, which we have shown previously to be the most prominent inhibitory receptors coexpressed on total CD8+ TILs in a variety of cancers including NSCLC28.