The prognostic implications of MYC-R with non-IG partners remain contentious, and while the prognostic significance of non-IG partners has been called into question [16, 24], the increased frequency of cases with no IG partner in YA patients and in DLBCL cases remains in keeping with increased heterogeneity of disease with advancing age across the pediatric/YA spectrum. The gene discussed is MYC; the disease is diffuse large B-cell lymphoma.