Although this pattern of activation by 5-HT is in agreement with a recent study demonstrating the activation of mainly the Gαq family and Gαz with little or no activation of other Gαi/o family members [43], the 5-HT2AR has also been reported to activate pathways downstream of the PTX-sensitive Gαi/o family, especially with respect to the pathophysiology of schizophrenia and the mechanism of action of hallucinogenic drugs [15, 20, 44, 45]. This evidence concerns the gene GNAQ and schizophrenia.