However, in a study of the effects of POLR3A mutations on mRNA and proteins in fibroblasts from patients with Wiedemann-Rautenstrauch syndrome, POLR3A mutations resulted in a decrease in wild-type POLR3A mRNA and POLR3A protein expression, while the expression of mutant proteins increased sharply 18. This evidence concerns the gene POLR3A and Wiedemann-Rautenstrauch syndrome.