This result was validated in the GSE66229 cohort; analysis showed that MAGEA11, CYP19A1, SHOX2, GRB14, SLC35E4, NEK5, AKAP5, MSI2, and KYNU were upregulated in the GC samples while PLCL1 was downregulated. The gene discussed is PLCL1; the disease is gastric cancer.