H3F3B and CENP-A are significantly positively correlated with all H3–H4 histone chaperones, and HIST1H4I is positively correlated with most (11 out of 19) H3–H4 histone chaperones (p < 0.05), suggesting that the expression of histone levels may also be upregulated in HCC when their corresponding chaperones are upregulated. This evidence concerns the gene CENPA and hepatocellular carcinoma.