Compared to the C3 subgroup, these survival differences could be explained in part by the C4 subgroup’s enrichment in Lum B BC and ECT6-7 (Epithelial cells, IFNαβ-myCAF, SPP1+ TAM) and the C1 subgroup’s abundance of ECT9 (Angio-EC, ECM-myCAF, TGFβ-myCAF) (Fig. 4E, F). The gene discussed is SPP1; the disease is breast cancer.