We identified TGFBR2 among the top-10 receptors expressed by Detox-iCAF which can drive key interactions with cancer cells, consistent with the functional assays shown above and recent data showing that the TGFβ2/TGFBR2 axis acts in the emergence of LRRC15+ ECM-myCAF in PDAC mouse models42. The gene discussed is TGFBR2; the disease is cancer.