Indeed, Detox-iCAF, IL-iCAF and IFNγ-iCAF recruit monocytes and induce a FOLR2+ tumor-associated macrophage (TAM) phenotype, while ECM-myCAF and TGFβ-myCAF promote TREM2+ TAM and NKG2A+ regulatory NK phenotypes. Here, TREM2 is linked to neoplasm.