In comparison to DCIS and MI-DCIS, IBC showed an accumulation in CD8+ T lymphocytes and myeloid cells (particularly in TREM2+ and SPP1+ TAM rather than FOLR2+ TAM) (Fig. 6C, D) but lower numbers of CAP (Fig. 6C). The gene discussed is TREM2; the disease is ductal breast carcinoma in situ.