SPP1 and cancer: ECM-myCAF, IFNαβ-myCAF, TGFβ-myCAF, SPP1+ TAM, TREM2+ TAM, regulatory lymphoid cells (FOXP3+ CD4+ Treg and NKG2A+ NKreg) and Angio-EC were detected in close vicinity to cancer cells, while Wound-myCAF, IL-iCAF, Detox-iCAF, FOLR2+ TAM, precursor T lymphocytes (SELL+ CD4+ and XCL1+ CD8+ T cells) and ap-EC were observed farther away from cancer cells (Fig. 4A and Supplementary Fig. 8B).