Phosphorylation of Ser72 by Akt and acetylation of K68 and K71 mediated by p300 contribute to the cytoplasmic localization and stability of Skp2, subsequently leading to the degradation of p27Kip1 and E-cadherin in breast cancer [8], prostate cancer [38], and liver cancer [39]. Here, EP300 is linked to Familial prostate cancer.