As shown in Table 3, SOX5 expression was significantly associated with N stage (p = 0.016), age (p = 0.046), tumor tissue site (p = 0.005), Breslow depth (p = 0.021), DSS event (p = 0.04), and PFI event (p = 0.004), indicating that SOX5 may participate in the occurrence and development of melanoma. The gene discussed is SOX5; the disease is neoplasm.