To test the potential involvement of these three PLIN2-recognizing E3 ligases (AIP4, TEB4, and UBR1) in the ubiquitin-mediated degradation of PLIN2 in RCC cells, a co-IP assay was next performed seeking to detect the ability of PLIN2 to interact with these ligases. The gene discussed is UBR1; the disease is renal cell carcinoma.