Several MAGMA-identified AD genetic risk factors also showed differential abundances in 5xFAD PV-INs as compared to WT PV-INs (e.g., decreased- Ppp1r9a, Mapt, Git1; increased- Arf5, Ndufb9, Stx1b (Fig. 5N). The gene discussed is ARF5; the disease is Alzheimer disease.