Besides its DNA-binding function, YBX1 plays versatile RNA-dependent roles in pre-mRNA splicing, mRNA stabilization and translational regulation of targeted mRNAs affecting various pathways of cancer development, including the maintenance of stemness36, SG formation by translational activation of the critical SG nucleator G3BP172, and stabilization of Myc transcripts59,60, which are potential oncogenic features of the OS RNA interactome characterized here. Here, YBX1 is linked to cancer.