This class of proteins is exemplified by PUM1 and PUM2, the La proteins (LARP1, LARP4, LARP4B), the IGF2BP family (IGF2BP1 and IGF2BP3), and the Y-box proteins YBX1 and YBX3 (Fig. 6b), most of which have been implicated in tumorigenesis and as hallmarks of cancer by targeting oncogenic/tumor suppressor transcripts9,51. The gene discussed is IGF2BP3; the disease is cancer.