The seven RNA-binding proteins (RBPs) earlier identified through computational analysis as constituting an RBP-related prognostic signature in osteosarcoma (OS) include zinc finger CCCH-type containing antiviral 1 (ZC3HAV1), RNA-binding motif protein 34 (RBM34), and insulin-like growth factor 2 mRNA-binding protein-2 (IGF2BP2)11. The gene discussed is IGF2; the disease is osteosarcoma.