MYCN and osteosarcoma: While such a positive feedback loop between IGF2BP3 as an RBP and c-Myc as a transcription factor has been shown for osteosarcoma in this study, this may be of wider interest in tumor biology and therapy as regulation of Myc by IGF2BP3 and vice versa has been attested in multiple tumor types37, and a positive feedback loop between IGF2BP3 and MycN promoting the proliferation of neuroblastoma cells has also been demonstrated88.