Our analyses supported causal effects of PTSD on autoimmune thyroid disease (beta = 0.11, 95% CI = [0.07–0.14]; causal versus sharing model p = 2.6 × 10−3) and CRP (beta = 0.05, 95% CI = [0.04–0.07]; causal versus sharing model p = 8.5 × 10−8) (Supplementary Table 7). The gene discussed is CRP; the disease is post-traumatic stress disorder.