IL22 and infectious colitis: The downstream effectors of IL-22, such as anti-microbial peptides RegIIIβ and RegIIIγ, were also dramatically diminished post-activation of β-catenin signaling in ILC3s (Supplementary Fig. 4m), indicating that activated Wnt/β-catenin signaling in ILC3s impairs host defense and promotes the development of infectious colitis.