In order to investigate the potential involvement of the Linc00857/miR-1290/GPX4 axis in the biological functions mediated by FOXP3 in GBM cells, we conducted experiments involving linc00857 knockdown, GPX4 knockdown, or miR-1290 overexpression in GBM cells that also had FOXP3 overexpression. This evidence concerns the gene FOXP3 and glioblastoma.