PKD1 and autosomal dominant polycystic kidney disease: Moreover, the increase in Panx1 mRNA expression in our precystic iKsp‐Pkd1−/− mice is relatively modest, in contrast to the clear increase in pannexin‐1 protein expression in cells lining cystic tissue in kidney biopsies of human ADPKD patients (Arkhipov et al., 2023; Verschuren et al., 2020).