PKD1 and cyst: For example, the zebrafish pronephros consists of only two nephrons with a shared glomerulus and the pkd2 zebrafish model only forms one large cyst, in contrast to the more complex microenvironment of early cystic and non‐cystic tissue in iKsp‐Pkd1−/− mice (Drummond et al., 1998; Poureetezadi & Wingert, 2016; Verschuren et al., 2020).