“Glucose‐insulin‐AMPK” expression was modeled against BMI by means of OPLS regression using the OPLS‐library in R (Thevenot et al., 2015) and prevalence of T2D by OPLS‐DA (as it is a dichotomous variable) The contribution of each individual gene in relation to the outcomes was obtained as Variable Importance in Projection (VIP). Here, INS is linked to type 2 diabetes mellitus.