COL4A3 and glioblastoma: GBM defects in AS arise from mutations in either of the three genes (Col4a3, Col4a4, or Col4a5 genes) that encode for three chains of type IV collagen, respectively (Hudson et al, 2003; Cosgrove et al, 2007; LeBleu et al, 2010; Cosgrove & Liu, 2017; Boudko et al, 2022).