These effects are most pronounced with dexamethasone due to its high protein binding affinity and longer half-life in cerebrospinal fluid.24 It was not possible to determine whether there were other contributing factors to this patient's delirium, and whether the prescribed dexamethasone was the primary cause; reporting of surrogate markers of other confounders, such as C-reactive protein, was poorly completed, and data on comedication were not collected. This evidence concerns the gene CRP and delirium.