The in-depth study on the immunology of melanoma suggested that the involvement of mutation in the genes such as v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), neuroblastoma RAS viral oncogene homolog (NRAS) and nuclear factor I (NFI), called as triple-wild type genotype, complicated the treatment process [9,10]. Here, NRAS is linked to melanoma.