This led us to hypothesize a regulatory role for C/EBP-β, a predominant oncogenic transcription factor in breast cancer, modulated by several receptor tyrosine kinases, such as EGFR, fibroblast growth factor receptor (FGFR), insulin receptor (IR), and IGF-1 receptor (IGF-1R) [39,40]. Here, IGF1R is linked to breast carcinoma.