Although the etiologies of the chronic retinal vascular diseases neovascular age-related macular degeneration (nAMD), diabetic macular edema (DME), and retinal vein occlusion (RVO) differ, the vascular endothelial growth factor (VEGF) pathway is a pivotal component of the pathophysiology underlying all 3 conditions.1 This evidence concerns the gene VEGFA and diabetic macular edema.