The risk of AIDS-related mortality was higher among PLWH with CD4 < 200 cells/μL (1.53 [1.16–2.02]), those with a history of an AIDS-defining illness (4.22 [3.35–5.32]), and those with 2 comorbidities (1.38 [1.02–1.98]) compared with those without comorbidities. Here, CD4 is linked to AIDS.