CD274 and cancer: We then investigated the relationship between NRAV and immune checkpoint genes, and found that expression was positively correlated with several immune checkpoint inhibitors, especially CD274 and CD276 in LGG and LIHC, however, a significant negative correlation was found between NRAV and many immune checkpoints in various cancers, including BRCA, CESC, ESCA, SKCM, and THCA (Suppl.