IQGAP3 and central nervous system cancer: Further analysis of IQGAP3 mRNA expression in glioma specimens categorized according to WHO grading (G2: 224 cases, G3: 243 cases, G4: 163 cases) in the TCGA database showed a progressive increase in IQGAP3 expression with the malignant grade of gliomas (p < 0.001), in addition, IQGAP3 expression was elevated in the wild-type IDH state as well as in glioma types without 1p/19q co-deletion (Fig. 1B).