The molecular mechanisms of GBM growth and invasion are extremely complex and include many factors, such as lactate dehydrogenases [36], mitogen-activated protein kinase kinase kinase 1(MAP3K1)/c-JUN signaling-axis [37], Hsa_circ_0072309 [38], RNA-binding motif protein 8A (RBM8A) [9], LINC01711 [10],COL1A2 [11], adipocyte enhancer-binding protein 1 (AEBP1) [39], Nucleobindin-2 [40], the cross-talk between Notch1 signaling and CXCL12/CXCR4 system [41], PRL1/USP36/Snail2 axis [42], Zinc finger CCCH-type containing 15 (ZC3H15) [43], circ_0060055 [44], and Rhoj/Rac1/PAK signaling [45], etc. This evidence concerns the gene MAP4K1 and glioblastoma.