In addition, several recent reports have suggested that GRIK1 may be an important factor for predicting the progression or prognosis of colorectal carcinoma [22], and breast tumor [23], it is the most prevalent kinds of cancer in women and one of the main causes of cancer deaths [24], and the progression of breast cancer is also related to many elements, such as metastasis-related gene signature [25], and has_circ_0000069 [26]. The gene discussed is GRIK1; the disease is cancer.