In the present study, we first examined the expression of IL-17 receptor A (IL-17RA, a major receptor), p300, Y705-phosphorylated STAT3 (i.e., p-STAT3), acetylated STAT3 (Ack-STAT3) and MMP19 both in NSCLC tissues and in the NSCLC cells stimulated by IL-17. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.