In the study, we selected and measured the expression of the genes which were reported to correlate with cancer metastasis according to the information of NSCLC tissue sequencing [8] and relevant literature [13–32], and found that the expression levels of IL-17RA, p300, p-STAT3, Ack-STAT3 and MMP19 were significantly higher than other gene in NSCLC samples, suggesting that these proteins may play some roles in NSCLC metastasis. This evidence concerns the gene STAT3 and cancer.