In this study, although we found that p300, p-STAT3 and Ack-STAT3 were increased in NSCLC tissues and in the cells stimulated with IL-17, and p300 overexpression or knockdown could elevate or reduce the levels of Ack-STAT3, p-STAT3 and MMP19 as well as the cell mobility, whether STAT3 phosphorylation can affect its acetylation and other parameters upon IL-17 has not been clear. The gene discussed is STAT3; the disease is non-small cell lung carcinoma.