CENP-E is upregulated in human neuroblastoma (Balamuth et al., 2010), retinoblastoma (Shi et al., 2021), melanoma (Uzdensky et al., 2014), esophageal cancer (Zhu et al., 2019), lung adenocarcinoma (Shan et al., 2019), gliomas (Rahane et al., 2019; Xu et al., 2020), non-small cell lung cancer (Hao and Qu, 2019; Ma et al., 2019), basal-like subtype among breast cancer (Kung et al., 2014), chemotherapy-resistant epithelial ovarian cancer (Ju et al., 2009), and castration-resistant PCa (Liang et al., 2017). This evidence concerns the gene CENPE and central nervous system cancer.