,37 There are about 70 antigens recognized by tumor-infiltrating B lymphocyte-derived antibodies,36 with p53 as a major antigen.38, 39, 40, 41, 42 Tumor-infiltrating B lymphocyte-derived antibodies and serum-derived autoantibodies against most antigens may originate and persist independently in cancer patients.36 Here, TP53 is linked to cancer.