,35 A growing body of evidence shows that HIF-1α forms a complex with p300 and CBP upon nuclear translocation to enhance the transcription of downstream genes, including angiogenic, glycolytic, and anti-apoptotic pathways.36, 37, 38 It has also been reported that tumor suppression can be achieved by disrupting the interaction between HIF-1α and its co-activator p300/CBP.39 Here, EP300 is linked to neoplasm.