RNA sequencing and genome-wide genotyping of monocyte-derived macrophages from patients with system sclerosis have revealed that the GSDMA rs3894194 risk variant contributes to several inflammatory pathways and system sclerosis susceptibility via up-regulation of glycolysis, hypoxia, and mTOR signaling and down-regulation of the IFN-γ response pathway.30 This evidence concerns the gene GSDMA and systemic sclerosis.