In brown adipose tissue, METTL3 deletion decreases the m6A modification and expression of the PR domain containing 16 (PRDM16), uncoupling protein 1 (UCP-1), and peroxisome proliferator-activated receptor gamma (PPARG) and thereby promotes high-fat diet-induced obesity.55 The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.