FBXL5 and pancreatic ductal adenocarcinoma: In protecting against pancreatic ductal adenocarcinoma (PDAC), overexpression of ALKBH5 reduces the intracellular iron level by regulating many iron-regulatory proteins, including F-box and leucine-rich repeat protein 5 (FBXL5), solute carrier family 25 member 28 (SLC25A28), and SLC25A37.122