Besides, METTL16 reprogrammes branched-chain amino acid (BCAA) metabolism by promoting the expression of BCAA transaminase 1 (BCAT1) and BCAT2, while depletion of METTL16 suppresses the initiation/development and stem cell self-renewal of acute myeloid leukemia (AML).111. The gene discussed is BCAT2; the disease is acute myeloid leukemia.