SREBF1 and obesity due to melanocortin 4 receptor deficiency: Metabolic abnormalities are important risk factors in many diseases, such as nonalcoholic steatohepatitis, liver fibrosis, fatty liver, and obesity.78, 79, 80 The protein expression of SREBP1 could be regulated by several post-translational modifications such as neddylation, phosphorylation, ubiquitination, and SDMA, regulating SREBP1 stability in cancer cells.